针刺研究

1996, (03) 18-21

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电针督脉经穴对急性脑缺血大鼠一氧化氮及内皮素的影响
Effects of Electroacupuncture at Du Meridian on Contents of Nitric Oxide and Endothelin in Rats with Acute Cerebral Ischemia

许能贵,许冠荪,钟平,王联发,朱舜丽,陈全珠
Xu Nenggui; Xu Gtlansun; Zhong Ping;Wang Lianfa; Zhu Shunli; Chen Quanzhu(Institude of Acuputncture and Merdisn, Anhui College of TCM, Hefei, 230038 )

摘要(Abstract):

30只大鼠随机分成对照组、脑缺血组和电针组。夹闻双侧顿总动脉使局部脑组织血流量急剧下降,造成急性脑缺血。分别测定正常、关闭时和电针督脉经穴后,大鼠脑组织及血中一氧化氮和内皮素的含量。结果发现:急性脑缺血时脑组织一氧化氮和内皮素含量增加,血浆内皮素水平升高和血清一氧化氮水平下降。电针督脉经穴后,脑组织及血中的一氧化氮和内皮素水平基本恢复到正常。提示电针督脉经穴可保护脑缺血所致神经元损伤,一氧化氮和内皮素可能参与电针的调整作用。
Thirty rats were randomly assigned to three groups, control group (10 cases), acute cerebral is-chemia group (10 cases) and electroacupuncture (EA) group (10 cases). The bilateral common carotidarteries were occluded, which caused sharp drop of regional cerebral blood flow and led acute cerebralischemia. Contents of nitric oxide (NO) and endothalin (ET) in the cerebral cortex and boold weredetermined in normal, during occluding and after EA of Du meridian (GV 20, GV 14) point in rats.It was found that in acute cerebral ischemia, the brain contents of NO and ET increased, the plasmelevel of ET elevated and serum level of NO decreased. After EA of Du meridian point, the levels of ETand NO in the brain and blood were returned significantly to normal. It is suggested that EA at Dumeridian have protective effect on neural damage induced by brain ischemia. NO and ET are possiblyinvolved in the regulative effect of EA.

关键词(KeyWords): 脑缺血;电针;督脉;一氧化氮;内皮素

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基金项目(Foundation): 国家中医药管理局科研基金

作者(Author): 许能贵,许冠荪,钟平,王联发,朱舜丽,陈全珠
Xu Nenggui; Xu Gtlansun; Zhong Ping;Wang Lianfa; Zhu Shunli; Chen Quanzhu(Institude of Acuputncture and Merdisn, Anhui College of TCM, Hefei, 230038 )

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