方继良;王小玲;王寅;洪洋;刘河生;刘军;王雷;薛超;周科华;宋明;刘保延;朱兵;

• 1:中国中医科学院广安门医院放射科脑功能成像研究室
• 2:中国中医科学院针灸研究所
• 3:中国中医科学院广安门医院针灸科
• 4:哈佛医学院马萨诸塞州总医院Athinoula A.Martinos生物医学影像中心

摘要(Abstract)：

目的:利用fMRI脑功能成像,比较电针时位于肢体的足三里穴及腹部的关元穴激活的脑功能区及其功能区网络连接的异同。方法:21名健康志愿者参加电针足三里穴、关元穴时的fMRI试验。分别在针刺前静息状态、留针、电针(15Hz,3次30s,间隔1min)、拔针后静息态采集fMRI脑功能数据,并记录电针任务时针感。采用t检验及卡方检验分析针感,SPM 2、短程和长程"中心度"法分析脑激活功能区及其之间的功能网络连接。结果:在电针电流无显著性差异条件下,电针足三里穴较关元穴诱导出了更强的胀满感及麻木感。电针两穴均产生了相似的前下扣带回-额叶内侧回网络的显著负激活效应,留针及电针能改变脑静息态脑功能默认功能模式,于额叶内侧回、扣带前回前下部短程脑功能网络出现了明显的即时针刺后效应。足三里穴较关元穴产生了更强的短程脑功能网络连接。结论:针刺足三里、关元穴具有显著相似的对脑边缘叶-额叶内侧皮层脑网络的调制作用,但也存在小的差异,体现穴位脑效应的相对特异性。

关键词(KeyWords)： 电针;fMRI;脑功能连接;穴位特异性;关元穴;足三里穴

Abstract:

Keywords:

基金项目(Foundation): 美国国立卫生研究院替代医学中心(NIH/NCCAM:1F05AT 003022-01-04);; 2008国家自然科学基金面上课题(30870668);; 2006广安门医院基金课题(504)

作者(Author): 方继良;王小玲;王寅;洪洋;刘河生;刘军;王雷;薛超;周科华;宋明;刘保延;朱兵;

Email:

DOI: 10.13702/j.1000-0607.2012.01.015

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