陈超;王宏才;翟煦;黄凤;吴冬;荣培晶;
CHEN Chao;WANG Hong-cai;ZHAI Xu;HUANG Feng;WU Dong;RONG Pei-jing;Institute of Acupuncturemoxibustion,China Academy of Chinese Medical Sciences;Graduate School,China Academy of Chinese Medical Sciences;Acupuncture and Moxibustion Department,Beijing Hospital of Traditional Chinese Medicine;Acupuncture and Moxibustion Department,Beijing Tongren Hosptial;

• 1:中国中医科学院针灸研究所
• 2:中国中医科学院研究生院
• 3:北京中医医院针灸科
• 4:北京同仁医院针灸科

摘要(Abstract)：

近年来,国内外对针灸治疗糖尿病做了一些机制研究。本文整理和分析了Pubmed及SCI数据库中相关文献,表明针灸治疗糖尿病可能是通过多个机制起作用,包括增强胰岛功能、减轻体质量及减少食物摄入、直接降低血糖、调整体内激素等机制。此外,针灸与降糖药物还有协同增效的作用,可取得更好的治疗效果,值得进一步研究。
Acupuncture has been used to treat diabetes mellitus(DM)for more than one thousand years.In the present paper,we review new progress of researches on the underlying mechanism of acupuncture intervention for DM.Results showed that acupuncture intervention can relieve DM by 1)reducing body weight through up-regulating leptin level,suppressing insulin resistance and appetite to reduce food intake possibly by way of down-regulating expression of neuropeptide Y in the hypothalamus,retarding gastric emptying velocity,increasing small intestinal peristalsis,raising plasma levels of glucagon-like peptide-1(GLP-1)and peptide YY,etc.;2)improving pancreas function,raising insulin sensitivity to improve insulin resistance possibly by activating AMP-activated protein kinase and sirtuin 1/peroxisome proliferator-activated receptorγcoactivator 1αsignaling,up-regulating activities of cholinergic nerve activity and nitric oxide synthase,and inhibiting apoptosis of pancreatic beta-cells;3)lowering blood glucose possibly by increasing anaerobic glucose metabolism,regulating activities of vagal and sympathetic nerves;4)adjusting the levels of related hormones such as melatonin,insulin,glucocorticold,epinephrine,etc.Moreover,acupuncture treatment combined with hypoglycemic drugs has a synergic effect in lowering blood glucose,suggesting apotentially effective approach for improving DM and being worthy of further studying in clinical practice.

关键词(KeyWords)： 针灸;糖尿病;作用机制;研究进展
Acupuncture therapy;Diabetes mellitus;Mechanism;Research progress

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 陈超;王宏才;翟煦;黄凤;吴冬;荣培晶;
CHEN Chao;WANG Hong-cai;ZHAI Xu;HUANG Feng;WU Dong;RONG Pei-jing;Institute of Acupuncturemoxibustion,China Academy of Chinese Medical Sciences;Graduate School,China Academy of Chinese Medical Sciences;Acupuncture and Moxibustion Department,Beijing Hospital of Traditional Chinese Medicine;Acupuncture and Moxibustion Department,Beijing Tongren Hosptial;

DOI: 10.13702/j.1000-0607.180009

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