针刺研究

2019, v.44(07) 538-542

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基于“肠道菌群-免疫反应”探讨针灸治疗缺血性脑卒中的作用机制
Possibility of acupuncture treatment of ischemic stroke via regulating intestinal flora-immune response

马继红;彭拥军;孙建华;朱冰梅;
MA Ji-hong;PENG Yong-jun;SUN Jian-hua;ZHU Bing-mei;Department of Acupuncture-moxibustion and Rehabilitation,Affiliated Hospital of Nanjing University of Chinese Medicine and Jiangsu Provincial Hospital of Traditional Chinese Medicine;Regenerative Medicine Center,West China Hospital,Sichuan University;

摘要(Abstract):

当前,肠道菌群受到越来越多国内外学者们的关注,其与缺血性脑卒中(IS)的相关性研究也逐渐成为脑卒中领域的新兴热点。研究表明,肠道菌群可能是一类新的危险因子,其通过细菌代谢产物或免疫机制可直接或间接影响IS的发生发展。而针灸对于IS、肠道菌群及免疫炎性反应均有一定的正向调节作用。因此,本文围绕三者的相关性展开讨论,并基于"肠道菌群-免疫反应"探讨针灸在治疗IS中的应用,推测针灸或许可以通过纠正紊乱的肠道菌群,降低免疫炎性反应,进而促进卒中损伤后的脑组织及神经功能恢复。
At present,intestinal flora has attracted more and more attention from scholars in China and foreign countries,and its association with ischemic stroke(IS)has gradually become a new research hotspot in the field of stroke.Studies also showed that intestinal flora may be a risk factor which directly or indirectly affects the occurrence and development of IS through bacterial metabolites and immune activities.In the present paper,we review the positive effect of acupuncture and moxibustion in alleviating the symptoms of limb locomotor,speech,swallowing dysfunction,cognition,etc.to improve the IS patients' daily life ability and in strengthening the cellular immune function of the body.In addition,acupuncture and moxibustion have a positive effect in regulating intestinal flora and immune inflammation.Hence,in the present paper,we discuss their relationship and the possibility of application of acupuncture and moxibustion therapies to the treatment of IS according to the theory of"intestinal floraimmune response".It is thus reasonable to speculate that acupuncture and moxibustion can be used to promote the recovery of brain tissue injury and neurological function after stroke via correcting intestinal flora disturbance and reducing immune inflammatory response.In-depth exploration of the role of"intestinal flora-immune response"in the treatment of IS and the specific regulatory function of acupuncture and moxibustion will provide new ideas and research approaches to reveal their mechanisms in the treatment of stroke from a new perspective.

关键词(KeyWords): 针灸;缺血性脑卒中;肠道菌群;免疫炎性反应
Acupuncture and moxibustion;Ischemic stroke;Intestinal flora;Immune inflammation

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(No.81574060、81001556);; 江苏省中医院院级课题省级康复中心建设专项项目(No.Y17kf02-5);; 中国博士后科学基金资助项目(No.2015M571790)

作者(Authors): 马继红;彭拥军;孙建华;朱冰梅;
MA Ji-hong;PENG Yong-jun;SUN Jian-hua;ZHU Bing-mei;Department of Acupuncture-moxibustion and Rehabilitation,Affiliated Hospital of Nanjing University of Chinese Medicine and Jiangsu Provincial Hospital of Traditional Chinese Medicine;Regenerative Medicine Center,West China Hospital,Sichuan University;

DOI: 10.13702/j.1000-0607.180786

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