针刺治疗单纯性肥胖症的实验研究The Experimental Study on Acupuncture Treatment of Simple Obesity in Rats
刘志诚,孙凤岷,韩燕,马骋,詹秀琴,赵飞浪,王沂争,朱苗花,刘臣
Liu Zhicheng; et al (Nanjing University of TCM, Nanjing, 210029)
摘要(Abstract)：
本文提示，采用高脂饲料喂养SD大鼠制造肥胖模型，致肥率达56．8％。本实验探讨了针刺和芬氟拉明（FFA）治疗肥胖大鼠的作用。结果表明，针刺对肥胖大鼠的摄食量、饮水量、体重、身长、Lee氏指数、心包、腹股沟和肾周脂肪量、主要脏器和腺体的重量、血中TG、TC、LDL－C、HDL－C、BG的含量及AI等指标的良性调整作用明显优于FFA。通过推挽灌流技术，我们观察了实验大鼠下丘脑外侧区（LHA）灌流液中单胺类介质含量的变化。结果示，对照组LHA中去甲肾上腺素（NA）含量显著高于正常组，针刺组LHA中NA含量显著低于对照组。提示，针刺时肥胖机体LHA的调控可能是针刺减肥关键因素之一。
The results showed that the obesity model of male SD rats might be obtained by high fat diet, the rate of production obesity was 56. 8%. The experiment studied that the obesity rats were cured by acupuncture and fenfluramine (FFA) respectively. The results showed that acupuncture had a good regulatory effect on the amount of food and water taken in, body weight, body length, Lee's index, fatty amount of body (pericardium, groin and perinephros), weight of main organs and gland, contents of TG,TC, LDL-C, HDL-C, BG in blood and AI. This action of acupuncture is better than that of FFA. Monoamine content of lateral hypothalamic area (LHA) in the experimental rats were observed by push-pull prefusion technology. The results showed that Noradrenaline (NA) content of LHA in control group was markedly higher than that in normal group, while the NA content of LHA in acupuncture group was markedly lower than that in control group. It suggests that the regulation of acupuncture on LHA was one of essential link in the antiobesity effect of acupuncture.
关键词(KeyWords)：
针刺;单纯性肥胖症;下丘脑外侧区;肥胖大鼠;推挽灌流
基金项目(Foundation): 国家自然科学基金
作者(Author):
刘志诚,孙凤岷,韩燕,马骋,詹秀琴,赵飞浪,王沂争,朱苗花,刘臣
Liu Zhicheng; et al (Nanjing University of TCM, Nanjing, 210029)
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DOI:
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