针刺研究

2020, v.45(05) 426-431

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

电针治疗阿尔茨海默病的β-淀粉样蛋白沉积相关机制研究进展
Mechanisms of electroacupuncture for improving Alzheimer’s disease from reducing β amyloid protein level

杨文丹;董卫国;
YANG Wen-dan;DONG Wei-guo;College of Acupuncture and Moxibustion, Fujian University of Traditional Chinese Medicine;College of Integrated Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine;

摘要(Abstract):

阿尔茨海默病(AD)属于最常见的痴呆疾病,电针疗法现已被广泛运用于AD的临床治疗,并取得较满意的疗效。本文主要从β-淀粉样蛋白生成与清除角度阐释电针治疗AD的作用机制,其中涉及自噬、氧化应激与能量代谢、炎性反应等相关机制,并展望一种综合的临床AD防治方案。
Alzheimer's disease(AD), a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary degeneration, is the most common type of dementia and has no incurable therapies at the moment. Electroacupuncture(EA) therapy has been widely used in clinical treatment of AD, and has attained approving effects. This article reviews the development of researches on the mechanisms of EA underlying improving AD by diminishing β amyloid protein(Aβ) neurotoxicity, from 1) up-regulating hippocampal cellular autophagy, 2) improving cerebral energy metabolism by activating oxidation stress-related factors peroxisome proliferator-activated receptor γ coactivator 1 alpha and sirtuin 1 in the hippocampus and frontal cerebral cortex, 3) relieving inflammatory reaction by lowering expression of tumor necrosis factor-alpha and high-mobility group box 1 and increasing expression of Interleukin 10, and 4) promoting degradation of Aβ_(1-42) by down-regulating expression of insulin degeneration enzyme, lipoprotein, transthyretin, apolipoprotein and α2 mcroglobulin. Meanwhile, a comprehensive clinical therapy of AD is proposed.

关键词(KeyWords): 电针;阿尔茨海默病;β-淀粉样蛋白;机制研究
Electroacupuncture;Alzheimer's disease;β amyloid protein;Mechanism research

Abstract:

Keywords:

基金项目(Foundation): 福建省卫生计生中青年骨干人才培养项目(No.2017-ZQN-63);; 福建省自然科学基金项目(No.2017J01541);; 福建省中医药科研项目(No.2017FJZYJC102);; 福建省科技厅科技平台建设项目(No.2015Y2001-64)

作者(Author): 杨文丹;董卫国;
YANG Wen-dan;DONG Wei-guo;College of Acupuncture and Moxibustion, Fujian University of Traditional Chinese Medicine;College of Integrated Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine;

Email:

DOI: 10.13702/j.1000-0607.180885

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享