针刺研究

2012, v.37(05) 422-427

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针灸治疗阿尔茨海默病机制的研究进展
Progress of Researches on Mechanisms of Acupuncture Intervention of Alzheimer's Disease

朱晶;国海东;邵水金;
ZHU Jing,GUO Hai-dong,SHAO Shui-jin(Teaching and Study Section of Anatomy,Basic Medical College,Shanghai University of Chinese Medicine,Shanghai 201203,China)

摘要(Abstract):

阿尔茨海默病(Alzheimer’s disease,AD)是威胁人类健康的主要疾病之一。本文就近年来国内有关针灸疗法治疗AD的研究进行了回顾,发现针灸可能通过调节神经递质的释放、保护神经元、提高神经营养因子含量、激活海马蛋白激酶、抑制脑组织炎性反应、调节异常蛋白质的水平和上调自噬活性水平等多条途径达到治疗AD的作用。深入探讨针灸治疗AD的作用机制,可为阐明AD的发病机制和寻找更为特异和有效的治疗靶点提供实验依据和理论基础。
Alzheimer's disease(AD) is one of the major diseases threatening the aged people's health.In the present paper,the authors reviewed development of studies on acupuncture treatment of AD from: 1) regulating release of neurotransmitters(cholinergic,amino-acids and monoamine neurotransmitters),2) protecting cerebral neurons from apoptosis(anti-oxidative stress,improving synaptic plasticity,and suppressing apoptosis),3) improving levels of neurotrophic factors,4) regulating hip-pocampal intracellular signaling,5) inhibiting inflammatory reactions of the brain tissue,6) adjusting the level of abnormal proteins(microtubule-associated protein,β-amyloid),and 7) up-regulating the level of autophagy activity.However,current experimental studies can not completely answer clinical questions due to limited model designs and complicated pathological mechanisms of AD.Many findings of biological indexes need being verified further.Reasonable therapeutic regimens of acupuncture formulated according to syndrome differentiation will help improving clinical curative effect and the corresponding research on new therapeutic targets may be helpful to our understanding about the mechanism of acupuncture.

关键词(KeyWords): 阿尔茨海默病;针刺疗法;神经递质;神经营养因子;保护机制;综述
Alzheimer's disease;Acupuncture therapy;Neurotransmitters;Neurotrophic factors;Protection mechanism;Review

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81102670);; 上海市教育委员会预算内科研项目(2010JW 03);; 上海市教育委员会重点学科建设项目(J 50301);; 上海中医药大学名师传承研究工程项目(2009120)

作者(Authors): 朱晶;国海东;邵水金;
ZHU Jing,GUO Hai-dong,SHAO Shui-jin(Teaching and Study Section of Anatomy,Basic Medical College,Shanghai University of Chinese Medicine,Shanghai 201203,China)

DOI: 10.13702/j.1000-0607.2012.05.018

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