针刺研究

1998, (01) 33-35

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电针对大鼠脑缺血后脑内神经细胞凋亡的影响
Effect of Electro-acupuncture on Neuronal Death Induced by Focal Cerebral Ischemia in Rats

晏义平,孙凤艳
Yan Yiping (Department of Pharmacology, Medical College of Shantou University, Shantou, 515031) Sun Fengyan (State Key Laboratory of Medical Neurobiology, Shanghai Medical University, Shanghai, 200032)

摘要(Abstract):

本研究运用TUNEL染色法观察电针对大鼠脑缺血后脑内神经细胞凋亡的影响。结果显示:在假手术组和单纯电针组,大鼠脑内未见神经细胞凋亡,脑缺血后12小时,大脑皮层梗塞区内大量的神经细胞凋亡,在缺血十电针组,大脑皮层梗塞区内神经细胞凋亡数目显著减少。结果表明:电针抑制脑缺血后脑内神经细胞凋亡。
In this study, TUNEL staining was used to observe the effect of electro-acupuncture(EA) on apoptotic neuronal death induced by focal cerebral ischemia in rats. The results were as follows: In the sham-operated group and the EA treated group, TUNEL positive stained cell was not detected in the brain. In the ischemic group, a large number of apoptotic neuronal cells were detected in the infarcted area of cerebral cortex at 12h postischemia. In the ischemia + EA treated group, the number of apoptotic neuronal cells in the infarcted area reduced significantly. The results suggest that EA inhibits apoptotic neuronal death induced by focal cerebral ischemia.

关键词(KeyWords): 脑缺血;凋亡;电针

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基金项目(Foundation): 国家教委博士点基金

作者(Author): 晏义平,孙凤艳
Yan Yiping (Department of Pharmacology, Medical College of Shantou University, Shantou, 515031) Sun Fengyan (State Key Laboratory of Medical Neurobiology, Shanghai Medical University, Shanghai, 200032)

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