针刺研究

2011, v.36(05) 383-387

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针灸治疗抑郁症的神经生物化学机制研究进展
Development of Studies on Neurochemical Mechanism of Acupuncture Underlying Improvement of Depression

余玲玲;刘儒鹏;高昕妍;刘坤;李亮;贲卉;荣培晶;
YU Ling-ling1,2,LIU Ru-peng1,GAO Xin-yan1,Liu Kun1,LI Liang1,BEN Hui1,RONG Pei-jing1(1Department of Physiology,Institute of Acu-moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;2Hubei University of Chinese Medicine,Wuhan 430061)

摘要(Abstract):

慢性应激导致机体神经生化系统的改变与抑郁症的发生关系密切,主要涉及神经递质或调质、神经内分泌激素、神经可塑性等的改变。针灸的抗抑郁机制与其对机体抑郁状态下紊乱的神经生化系统的良性调节作用有关。本文总结了近年针灸治疗抑郁症相关实验研究进展,从(1)单胺类神经递质及其受体,(2)γ-氨基丁酸和谷氨酸,(3)神经肽Y,(4)下丘脑-垂体-肾上腺轴和下丘脑-垂体-甲状腺轴活动,及(5)脑源性神经营养因子等五个方面对针灸治疗抑郁症的神经生化机制进行了总结,并对针灸治疗本病的研究进行进一步展望。
Chronic stress often results in neurochemical changes in the central nervous system and may lead to the onset of depression.These neurochemical changes refer to alterations of activities of neurotransmitters,neuromediators,hormones and neuronal plasticity,etc.The underlying mechanism of acupuncture in the antidepressant effect is related to its regulatory effect on the neurochemical imbalance.In the present review,the authors summarize the progress of experimental researches on acupuncture treatment of depression from 1) monoamines neurotransmitters and their receptors,2) gamma-aminobutyric acid and glutamate,3) neuropeptide Y,4) hypothalamus-pituitary-adrenal axis and hypothalamus-pituitary-throid axis activities,and 5) brain-derived neurotrophic factor.In addition,the authors also make an evaluation on the insufficiency of current studies and put forwards some suggestions on the future study.

关键词(KeyWords): 针灸;抑郁症;神经生化机制
Acupuncture;Depression;Neurochemical mechanism

Abstract:

Keywords:

基金项目(Foundation): 北京市自然科学基金重点项目(No.7111007)

作者(Authors): 余玲玲;刘儒鹏;高昕妍;刘坤;李亮;贲卉;荣培晶;
YU Ling-ling1,2,LIU Ru-peng1,GAO Xin-yan1,Liu Kun1,LI Liang1,BEN Hui1,RONG Pei-jing1(1Department of Physiology,Institute of Acu-moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;2Hubei University of Chinese Medicine,Wuhan 430061)

DOI: 10.13702/j.1000-0607.2011.05.015

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