针刺研究

2020, v.45(06) 508-512

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针刺基于Wnt/β-catenin通路治疗阿尔茨海默病的实验研究进展
Advances in the experimental mechanism of acupuncture in the treatment of Alzheimer's disease based on Wnt/β-catenin pathway

李笑笑;李广大;马艳艳;程荣;朱家明;韩永升;
LI Xiao-xiao;LI Guang-da;MA Yan-yan;CHENG Rong;ZHU Jia-ming;HAN Yong-sheng;Graduate School of Anhui University of Chinese Medicine;Hospital Affiliated to Institute of Neurology, Anhui University of Chinese Medcine;Institute of Neurology, Anhui University of Chinese Medicine;

摘要(Abstract):

研究证实,Wnt/β-catenin信号通路参与了阿尔茨海默病(AD)的发生发展过程。针刺通过对该通路的各靶点及整体的调控实现治疗AD的作用。本文通过对近年来针刺治疗AD的研究进行了回顾和梳理,分别从针刺对Wnt/β-catenin信号通路重要成分(Wnt蛋白、β-catenin、糖原合成酶激酶-3β)及整体、多药耐药性蛋白(ABCB1)、低密度脂蛋白受体相关蛋白-1(LRP-1)等方面的调控作用进行综述。
Alzheimer's disease is a neurodegenerative disease closely related to age, which is characterized by cognitive and memory impairment. Extensive studies have confirmed that Wnt/β-catenin signal pathway is involved in the occurrence and development of Alzheimer's disease. With the characteristics of holistic concept and syndrome differentiation, acupuncture is widely used in clinic. Acupuncture plays a role in the treatment of Alzheimer's disease through the regulation of each target and the whole of the pathway. The author reviewed and combed the research on acupuncture treatment of Alzheimer's disease in recent years, and reviewed the regulatory effects of acupuncture on the important components of Wnt/β-catenin signal pathway(Wnt protein, β-catenin, glycogen synthase kinase-3β) and whole, ATP-binding cassette subfamily B member 1(ABCB1), low density lipoprotein receptor associated protein-1(LRP-1).

关键词(KeyWords): 阿尔茨海默病;Wnt/β-catenin信号通路;针刺;调控作用
Alzheimer's disease;Wnt/β-catenin signal pathway;Acupuncture;Regulatory effect

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(No.81774425)

作者(Author): 李笑笑;李广大;马艳艳;程荣;朱家明;韩永升;
LI Xiao-xiao;LI Guang-da;MA Yan-yan;CHENG Rong;ZHU Jia-ming;HAN Yong-sheng;Graduate School of Anhui University of Chinese Medicine;Hospital Affiliated to Institute of Neurology, Anhui University of Chinese Medcine;Institute of Neurology, Anhui University of Chinese Medicine;

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DOI: 10.13702/j.1000-0607.200016

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