针刺研究

2021, v.46(09) 794-799

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艾灸对遗忘型轻度认知障碍记忆功能及相关血清蛋白标志物的影响
Effect of moxibustion on memory function and related serum protein markers in patients with amnestic mild cognitive impairment

汪海燕;李思妤;胡琼;于海洋;张虹;
WANG Hai-yan;LI Si-yu;HU Qiong;YU Hai-yang;ZHANG Hong;Department of Acupuncture and Moxibustion, The Affiliated Hospital of Gansu University of Chinese Medicine;School of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine;Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine;

摘要(Abstract):

目的:观察"三才益智"灸法干预方式对遗忘型轻度认知障碍(aMCI)患者记忆功能的改善情况及对相关血清蛋白标志物Aβ1-42、Tau、磷酸化Tau(P-tau)的影响,初步探讨其外周机制。方法:采用随机数字表法将纳入的120例aMCI患者随机分为艾灸组和药物组,每组60例。其中艾灸组脱落6例,剔除5例,最终完成49例;药物组脱落8例,剔除6例,最终完成46例。艾灸组给予艾灸百会、神阙和涌泉(双侧),每次20 min,隔日1次,共治疗8周;药物组口服盐酸多奈哌齐片5 mg/次,1次/日,连续服用8周。以Rivermead行为记忆能力测验(RBMT)及蒙特利认知评估(MoCA)量表作为疗效评价指标,分析评价两组治疗后的临床疗效。采用酶联免疫吸附测定法检测治疗前后两组患者血清Aβ1-42、Tau、P-tau水平的变化。结果:与本组治疗前比较,两组患者治疗后RBMT评分和MoCA评分均升高(P<0.05);艾灸组患者治疗后血清Aβ1-42、Tau、P-tau水平降低(P<0.05),药物组患者治疗后血清Aβ1-42、P-tau水平降低(P<0.05)。与同时点药物组比较,治疗后艾灸组RBMT评分显著提高(P<0.05)。结论:"三才益智"灸法能改善aMCI患者的认知功能,对aMCI患者血清Aβ1-42、Tau和P-tau水平产生影响,这可能是"三才益智"灸法改善aMCI患者认知功能的机制之一。
Objective To observe the clinical effect of moxibustion therapy based on "sancai yizhi"(benefiting the intelligence) therapy on the improvements of memory function and serum protein markers, Aβ1-42, Tau and phosphorylated Tau(P-tau) in the patients with amnestic mild cognitive impairment(aMCI), and has a preliminary exploration on its peripheral mechanism. Methods A total of 120 patients with aMCI were divided into a moxibustion group and a medication group using a random number table, 60 patients in each group. In the moxibustion group, 6 cases were dropped out and 5 cases were withdrawn, and then 49 cases accomplished the trial finally. In the medication group, 8 cases were dropped out and 6 ceases were withdrawn, thus 46 cases finally accomplished the trial. In the moxibustion group, moxibustion therapy was provided at Baihui(GV20), Shenque(CV8) and bilateral Yongquan(KI1), once every other day, 20 minutes each time, totally for 8 weeks. In the medication group, donepezil hydrochloride tablets were administered orally, 5 mg once a day, consecutively for 8 weeks. The scores of Rivermead behavioral memory test(RBMT) and Monterey cognitive assessment(MoCA) scale were adopted as the indicators to evaluate the therapeutic effect after treatment in the two groups. Enzyme linked immunosorbent assay(ELISA) was used to detect the changes of the levels of serum protein marker levels, i.e. Aβ1-42, Tau and P-tau before and after treatment in the patients of two groups. Results Compared with the scores before treatment, RBMT score and MoCA score all increased after treatment in the patients of two groups(P<0.05). Compared with the medication group at the same time points, RBMT score increased significantly(P<0.05) in the moxibustion group after treatment. In the moxibustion group, as compared with the levels before treatment, the levels of serum Aβ1-42,Tau and P-tau decreased after treatment in the patients(P<0.05). But in the medication group, the levels of serum Aβ1-42 and P-tau were reduced(P<0.05). Compared with the medication group at the same time points, there were no significant differences in the changes of serum Aβ1-42,Tau and P-tau in the moxibustion group(P>0.05). Conclusion Moxibustion therapy based on "sancai yizhi" theory improves the cognitive function in the patients with aMCI and it affects the levels of serum Aβ1-42, Tau and P-tau, which may be the reason for the improvement of cognitive function in the patients with aMCI.

关键词(KeyWords): 遗忘型轻度认知障碍;“三才益智”灸法;盐酸多奈哌齐;神经心理学量表;Aβ;Tau;磷酸化Tau
Amnestic mild cognitive impairment;"Sancai yizhi" moxibustion;Donepezil hydrochloride;Neuropsycholo-gical scale;Aβ;Tau;Phosphorylated Tau

Abstract:

Keywords:

基金项目(Foundation): 四川省成都市科技局科技惠民计划项目(No.2015-HM01-00539-SF);; 四川省科学技术厅四川省重点研发项目(No.2018SZ0072)

作者(Author): 汪海燕;李思妤;胡琼;于海洋;张虹;
WANG Hai-yan;LI Si-yu;HU Qiong;YU Hai-yang;ZHANG Hong;Department of Acupuncture and Moxibustion, The Affiliated Hospital of Gansu University of Chinese Medicine;School of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine;Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine;

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DOI: 10.13702/j.1000-0607.200932

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